CorVita Science – CorVita Science Foundation

The CorVita Science Foundation

The CorVita Science Foundation (CSF) is a Chicago based nonprofit dedicated to the accessibility and advancement of cardiovascular clinical and translational science at home and abroad.

While the academic medical center is the traditional realm for clinical trials, the CSF is devoted to fostering an opportunity that offers global cardiovascular research projects and collaboration for regional residents, fellows, and clinical cardiologists. Our inclusive approach, and focus for ongoing education, training and mentorship, is designed to improve care and outcomes, to heighten clinical knowledge and to expand a high-quality, expert and experienced research infrastructure in order to realize clinical trial enrollment efficiencies.

CSF partnerships with pharmaceutical and biotechnology companies will introduce new technologies and innovations through clinical trials into communities that previously had limited access. CSF will provide the infrastructure, educational content and direction as well as clinical trial oversight to advance the efficiency and quality of clinical research and education amongst our partners and members.

The Foundation will work with hospital centers and physician medical groups to recruit highly skilled and well trained cardiologists and clinical/research personnel into their organizations. By partnering with CSF, these hospital academic centers and physician groups will have an advantage over organizations that don’t offer clinical trials due to lack of infrastructure and will promote innovative thinking. Recruiting highly skilled clinicians and offering clinical research trials will entice patients to stay within their communities.

The CSF is in the early stages of a multi-phase, multi-year strategic plan to establish a global operation of research and clinical fellows. We invite all interested cardiologists, industry partners and particularly next-generation medical students, residents, fellows and physicians who may be interested in participating in a global cardiovascular research organization by becoming charter council members and sharing their insights in order to develop our programs and relationships.

Lectures, Presentations & Discussions

Coming soon.

Publications

Project Briefs

FY2019

Quast ABE, Baalman SWE, Brouwer TF, Smeding L, Wilde AAM, Burke MC, Knops RE. A novel tool to evaluate the implant position and predict defibrillation success of the subcutaneous implantable defibrillator: The PRAETORIAN score. Heart Rhythm 2019; 16(3): 403-410.

Rajamannan NM. TIEG1 is upregulated in Lrp5/6-mediated valve osteogenesis. J Cell Biochem. 2018 Sep 23. doi: 10.1002/jcb.27606.

Essandoh MK, Mark GE, Aasbo JD, Joyner CA, Sharma S, Decena BF, Bolin ED, Weiss R, Burke MC, McClernon TR, Daoud EG, Gold MR. Anesthesia for subcutaneous implantable cardioverter defibrillator implantation: Perspectives from the clinical experience of a U.S. panel of physicians. PACE 2018; doi: 1111/pace. 13664

Theuns DAMJ, Brouwer TF, Jones PW, Allavatam V, Donnelley, S, Auricchio A, Knops RE, Burke MC. Prospective blinded evaluation of a novel sensing methodology designed to reduce inappropriate shocks by the subcutaneous implantable cardioverter defibrillator. Heart Rhythm 2018; 15(10): 1515-1522.

Quast ABE, Tjong FVY, Koop BE, Wilde AAM, Knops RE, Burke MC. Device orientation of a leadless pacemaker and subcutaneous implantable cardioverter-defibrillator in canine and human subjects and the effect on intrabody communication. Europace. 2018; 20(11): 1866-1871.

Frankel DS, Burke MC, Callans DJ, Stivland TM, Duffy E, Epstein AE, Impact of Body Mass Index on Safety and Efficacy of the Subcutaneous Implantable Cardioverter-Defibrillator. JACC Electrophysiology 2018, 4(5): 652-659

Amin AK, Gold MR, Burke MC, Knight BP, Rajjoub MR, Duffy E, Husby M, Stahl WK, Weiss R. Factors associated with high voltage impedance and subcutaneous implantable defibrillator ventricular fibrillation conversion success. Circ Arrhythmia and Electrophysiology 2019; 12(4): e006665. Doi: 10.1161/CIRCEP.118.006665

Burke MC, Moss JD, Ludmer P, Sharma AD, Barr CS, O’Neill PG, Lee MA, Skehan JD,Cho S, Kang S, Toff W. Comparisons and Observations during Multiple Posture Analysis of Resting Electrocardiograms (COMPARE) Study. In review

Brouwer TF, Burke MC, Knops RE. Letter regarding: Ventricular fibrillation conversion testing after implantation of a subcutaneous implantable cardioverter defibrillator: Report from the national cardiovascular data registry. Circulation 2018

FY2018

Essandoh MK, Mark GE, Aasbo JD, Joyner CA, Sharma S, Decena BF, Bolin ED, Weiss R, Burke MC, McClernon TR, Daoud EG, Gold MR. Anesthesia for subcutaneous implantable cardioverter-defibrillator implantation: Perspectives from the clinical experience of a U.S. panel of physicians. Pacing Clin Electrophysiol. 2018 May 13. doi: 10.1111/pace.13364.

Frankel D, Burke MC, Callans D, Stivland T, Duffy E, Epstein A. (2018). Impact of Body Mass Index on Safety and Efficacy of the Subcutaneous Implantable Cardioverter-Defibrillator. JACC: Clinical Electrophysiology. 10.1016/j.jacep.2017.11.019.

Quast AF, Tjong F, Koop B, Wilde AAM, Knops RE, Burke MC. (2018). Device orientation of a leadless pacemaker and subcutaneous implantable cardioverter-defibrillator in canine and human subjects and the effect on intrabody communication. EP Europace. 10.1093/europace/euy019.

Theuns DAMJ, Brouwer TF, Jones P, Allavatam V, Donnelley S, Auricchio A, Knops RE, Burke MC, A Prospective, Blinded Evaluation Of A Novel Sensing Methodology Designed To Reduce Inappropriate Shocks By The Subcutaneous Implantable Defibrillator, Heart Rhythm (2018), doi: 10.1016/j.hrthm.2018.05.011

Tjong FVY, Brouwer TF, Koop B, Soltis B, Shuros A, Schmidt B, Swackhamer B, Quast AEB, Wilde AAM, Burke MC, Knops RE. Acute and 3-Month Performance of a Communicating Leadless Anti-tachycardia Pacemaker and Subcutaneous Implantable Defibrillator. JACC Clin Electrophysiol. 2017 Dec 26;3(13):1487-1498. doi: 10.1016/j.jacep.2017.04.002. Epub 2017 May 31.

Waxman AB, McElderry HT, Gomberg-Maitland M, Burke MC, Ross EL, Bersohn MM, Pangarkar SS, Tarver JH, Zwicke DL, Feldman JP, Chakinala MM, Frantz RP, Thompson GB, Torres F, Rauck RL, Clagg K, Durst L, Li P, Morris M, Southall KL, Peterson L, Bourge RC. Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure. Chest. 2017 Dec;152(6):1128-1134. doi: 10.1016/j.chest.2017.04.188. Epub 2017 Jun 3.

Gold MR, Aasbo JD, El-Chami MF, Niebauer M, Herre J, Prutkin JM, Knight BP, Kutalek S, Hsu K, Weiss R, Bass E, Husby M, Stivland TM, Burke MC. Subcutaneous implantable cardioverter-defibrillator Post-Approval Study: Clinical characteristics and perioperative results. Heart Rhythm. 2017 Oct;14(10):1456-1463. doi: 10.1016/j.hrthm.2017.05.016. Epub 2017 May 11.

Board of Directors

Martin C. Burke, DO

President

A former chief of cardiology at a top-tier academic medical center, he is a respected teacher, mentor and academician who has authored and co-authored many articles in esteemed scientific journals. Dr. Burke is a national and international authority in cardiac electrophysiology, with emphasis on the basic mechanisms and clinical applications of cardiac defibrillation. His clinical research interests encompass the treatment of cardiac arrhythmias through intracardiac device and radiofrequency catheter ablation techniques, including atrial fibrillation and ventricular tachycardia, and laser removal of therapeutic devices for cardiac arrhythmias.

Ravi Ramana, DO

Secretary of Treasury

Dr. Ramana specializes in coronary diagnostic and interventional procedures. His special interests include percutaneous therapies for valvular disease, including Transcatheter Aortic Valve Replacement (TAVR). Currently, he serves as the Medical Director of the Multi-disciplinary Valve Program at Advocate Christ Medical Center and is a lead investigator on a number of national research trials evaluating these newer therapies. Dr. Ramana has published in peer-reviewed original manuscripts and two comprehensive book chapters in cardiovascular medicine textbooks. He has served as faculty and presented at national cardiovascular meetings including TCT, AHA, and SCAI.

Reinoud E. Knops, MD, PhD

Member at Large

Dr. Knops is a world renown electrophysiologist whose professional activity revolves around training the next generation of cardiac electrophysiology scientists in the field of cardiac implantable electronic device development and progress. Dr. Knops is a staff scientist in Cardiology at the University of Amsterdam practicing within the Academic Medical Center. His expertise is recognized world-wide and his peer review scholarly activity is highly regarded and significant in the field.

Tom F. Brouwer, MD, PhD

Member at Large

Dr. Brouwer recently defended successfully his thesis: S-ICD: The New Kid on the Block and has begun his clinical training in internal medicine and cardiology at the University of Amsterdam Academic Medical Center. Dr. Brouwer has broad interests beyond his thesis and has been peer recognized for his metanalyses and epidemiology work in cardiovascular disease and prevention. Dr. Brouwer is a natural team builder and accomplished scientist. His current scholarly pursuits involve predictive analytics in medication adherence and pattern recognition in electrocardiography.

Corvita Science Foundation

The CorVita Science Foundation

Lectures, Presentations & Discussions

Publications

Calcification and Thrombosis as Mediators of Bioprosthetic Valve Deterioration

Building a Culture of Scholarly Activity in IM Programs

Project Briefs

Board of Directors

Martin C. Burke, DO

Ravi Ramana, DO

Reinoud E. Knops, MD, PhD

Tom F. Brouwer, MD, PhD